At this point, the vast majority of people familiar with cannabis have an understanding about THC (tetrahydrocannabinol) and CBD (cannabidiol) and their compounds, however did you know there are numerous comparative compounds in cannabis? A lesser-known cannabinoid called cannabigerol (CBG), while not present in huge amounts in many strains, it’s regardless worth learning about for various reasons.

So What is CBG, Anyway?

One of these minor cannabinoids is cannabigerol (CBG), which is picking up attention for its proclaimed anti-bacterial, anti- microbial, and anti-inflammatory properties. CBG is still catching up with the mainstream hype of CBD, this cannabinoid may before you know it become the new talk of the town product for consumers due to its wide array of medicinal properties.

CBG is the “mother” cannabinoid of numerous different cannabinoids present in the cannabis plant. Basically, it’s delegated a minor cannabinoid, however CBG is a critical cannabis compound. In the cannabis plant, CBG can be found as cannabigerolic acid (CBGA), which is the foundation of the three fundamental parts of cannabinoids that incorporate cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), and cannabichromenic acid (CBCA). CBGA changes into these three parts of cannabinoid through explicit enzymes referred to as synthases as the cannabis plant develops. Since most CBGA is synthesized into these other molecular structures, there are exceptionally low concentrations of this cannabinoid in develop cannabis plants. Through a procedure known as decarboxylation (where heat is applied to the acidic types of these cannabinoids), CBGA, CBDA, THCA, and CBCA all lose one carbon group. They are then changed into the more commonplace types of CBG, CBD, THC, and CBC. This is viewed as the active state of these compounds and where the vast majority of their medicinal benefits are contained.

So What Are the Benefits of CBG?

Like other cannabinoids, CBG has appeared to contain various restorative properties and could play an important job in several disorders and diseases. CBG isn’t psychoactive, which means it won’t get you high. Truth be told, much like CBD, it’s accepted that CBG could counter a portion of the negative effects of THC-rich strains, for example, anxiety and paranoia. CBG has demonstrated to be a partial agonist of CB1 receptors (those found in high concentrations in the central nervous system), which explains why it could mitigate the impacts of THC. While CBG has some binding affinity to CB2 receptors, the mechanisms here aren’t also known.

CBG’s Potential Medicinal Benefits

CBG has been found to be very effective of specific physiological systems and issues, and the results for therapeutic medicinal use are promising:

• CBG was found to be effective in decreasing the inflammation characteristic of inflammatory bowel disease in mice. Borrelli F, e. (2019). Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. – PubMed – NCBI. [online] Ncbi.nlm.nih.gov. Retrieved from : https://www.ncbi.nlm.nih.gov/pubmed/23415610

• CBG is an effective antibacterial agent, particularly against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to several classes of drugs. Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., … Rahman, M. M. (2008, August). Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18681481

• In a study that focused on the effects of five different cannabinoids on bladder contractions, CBG tested best at inhibiting muscle contractions, so it might become the next focus on helping prevent bladder dysfunction disorders. Pagano, E., Montanaro, V., Di Girolamo, A., Pistone, A., Altieri, V., Zjawiony, J. K., … Capasso, R. (2015, June). Effect of Non-Psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26197538

• CBG is showing promising result in fighting cancer. Specifically, CBG potently blocks transient receptor potential (TRP) M8 (TRPM8), activates TRPA1, TRPV1 and TRPV2 channels, blocks 5-hydroxytryptamine receptor 1A (5-HT1A) receptors and inhibits the reuptake of endocannabinoids. In other words, CBG was shown to block receptors that cause cancer cell growth. It was shown to inhibit the growth of colorectal cancer cells in mice, thereby slowing colon cancer growth. CBG inhibited tumors and chemically-induced colon carcinogenesis, therefore demonstrating a very exciting possibility for a cure for colorectal cancer. Borrelli, F., Pagano, E., Romano, B., Panzera, S., Maiello, F., Coppola, D., … Izzo, A. A. (2014, December). Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25269802

Researchers are amped up for these underlying CBG results and are advancing future research with CBG alone or CBG in combination with different cannabinoids and therapies for the treatment of numerous diseases. Since it is non-psychotropic, CBG has a promising wide scope of potential applications for the ailments referenced above, yet additionally as a pain reliever, treatment for psoriasis, and as an antidepressant.

Is There a Future for CBG?

While CBG is one of the most important cannabinoids there is…it isn’t as readily available as other cannabinoids.  This is because CBG is typically converted into other cannabinoids as the cannabis plant matures. This definitely makes CBG one of the rarer cannabinoids that exist.

Leafywell has been on the forefront of offering CBG to their clients and consumers for the past several years. With Leafywell’s new partnership with Shari Kaplan Stellino, found and CEO of Cannected Biotechnology, they have an in offering expert-level input of new formulations of their popular CBG (Cannabigerol) containing products. In conjunction with their current CBG line of products, LeafyWell will be launching its first CBG signature serious line that will have added medicinal value in 2020. It’s a Doctors choice amongst their board of advisors.

LeafyWell, specializes in the manufacturing and distribution of full spectrum CBD (Cannabidiol), CBG (Cannabigerol) product lines including tinctures, oils, creams, lotions, edibles, and a full line of pet products available online and at select retailers nationwide. To see the LeafyWell brand products or if you have any questions, visit www.LeafyWell.com, call (888) 315-6339 or email admin@LeafyWell.com.